Ionescu J, Eskenasy A
Morphol Embryol (Bucur). 1976 Jan-Mar;22(1):47-51.
The development of lung granulomas induced in rabbits by an intravenous injection of the complete Freund adjuvant containing dog pulmonary proteins was followed by histologic and histoenzymatic methods. By comparison with normal rabbit lungs. the developing structures of the induced lung granulomas showed an increase of all tested enzymes at 15 days, and a secondary intensity decrease of the activity of malic dehydrogenase, of acid and alkaline phosphatases, and of alanyl-aminopeptidase at 30 days. Only the hydroxyproline-epimerase showed at these intervals an increasing activity in the lung granulomas. The developed reticulinic fibrils appeared to have a highly intense alkaline phosphatase activity.
通过组织学和组织酶学方法，追踪静脉注射含有犬肺蛋白的完全弗氏佐剂诱导兔产生肺肉芽肿的过程。与正常兔肺相比，诱导的肺肉芽肿的发育结构在第15天时所有测试酶的活性均增加，而在第30天时苹果酸脱氢酶、酸性和碱性磷酸酶以及丙氨酰氨基肽酶的活性出现继发性强度降低。只有羟脯氨酸表异构酶在这些时间间隔内，在肺肉芽肿中显示出活性增加。发育形成的网状纤维似乎具有高强度的碱性磷酸酶活性。
