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胰腺癌发生过程中的胰腺造影结果。

The results of pancreatography during pancreatic carcinogenesis.

作者信息

Takahashi M, Pour P

出版信息

Am J Pathol. 1978 Apr;91(1):57-70.

PMID:645822
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2018164/
Abstract

Systematic histologic-pancreatographic examination of the pancreas during pancreatic ductal carcinogenesis revealed both specific and nonspecific diagnostic criteria. Ductal changes due to hyperplasia of ductal epithelium were recognized as distention rather than narrowing. This condition, however, occurred in limited numbers during advanced ductal alteration and was found to be an insignificant criterion. The most reliable tumor marker was complete ductal obstruction: ductal deterioration (displacement, deformity) occurred in 63% of the tumor cases, a pooling effect occurred in 44%, and a filling defect occurred in 42%. In both histologic and pancreatographic studies was found the "chain of lakes" caused by ductular proliferation or adenomas both of which seem to represent precursor stages of adenocarcinomas. Some neoplasms escaped diagnosis, due to either their small size, anatomic location, or specific histologic patterns. The data indicated that pancreatography per se as an early detection tool is unreliable.

摘要

在胰腺导管癌发生过程中对胰腺进行系统的组织学-胰腺造影检查揭示了特异性和非特异性诊断标准。导管上皮增生引起的导管变化被认为是扩张而非狭窄。然而，这种情况在晚期导管改变期间数量有限，并且被发现是一个无足轻重的标准。最可靠的肿瘤标志物是完全导管阻塞：63%的肿瘤病例出现导管破坏（移位、畸形），44%出现聚集效应，42%出现充盈缺损。在组织学和胰腺造影研究中均发现由小导管增生或腺瘤引起的“串珠样改变”，这两者似乎都代表腺癌的前期阶段。一些肿瘤由于其体积小、解剖位置或特定的组织学模式而漏诊。数据表明，胰腺造影本身作为一种早期检测工具是不可靠的。

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本文引用的文献

1
Patterns in cancer mortality in the United States: 1950-1967.美国1950 - 1967年癌症死亡率模式
Natl Cancer Inst Monogr. 1971 May;71(33):1-594.
2
Endoscopic pancreatocholangiography. II. The pathological endoscopic pancreatocholangiogram.内镜胰胆管造影术。II. 病理内镜胰胆管造影照片
Gastroenterology. 1972 Aug;63(2):227-34.
3
Cancer of the pancreas. Available epidemiologic information and its implications.胰腺癌。现有流行病学信息及其意义。
Cancer. 1973 May;31(5):1231-6. doi: 10.1002/1097-0142(197305)31:5<1231::aid-cncr2820310529>3.0.co;2-c.
4
Cancer of the pancreas induced in the Syrian golden hamster.叙利亚金黄地鼠诱发的胰腺癌。
Am J Pathol. 1974 Aug;76(2):349-58.
5
Epidemiology of cancer of the pancreas.胰腺癌的流行病学
J Natl Cancer Inst. 1973 Mar;50(3):645-67. doi: 10.1093/jnci/50.3.645.
6
Endoscopic pancreato-cholangiography. A preliminary report on technique and diagnostic significance.内镜胰胆管造影术。技术及诊断意义的初步报告。
Am J Roentgenol Radium Ther Nucl Med. 1973 Feb;117(2):437-45. doi: 10.2214/ajr.117.2.437.
7
A new approach for induction of pancreatic neoplasms.一种诱导胰腺肿瘤的新方法。
Cancer Res. 1975 Aug;35(8):2259-68.
8
The pancreas of the Syrian hamster (Mesocricetus auratus). I Anatomical study.叙利亚仓鼠（金仓鼠）的胰腺。I解剖学研究。
Lab Anim Sci. 1977 Jun;27(3):336-42.
9
Islet cells as a component of pancreatic ductal neoplasms. I. Experimental study: ductular cells, including islet cell precursors, as primary progenitor cells of tumors.胰岛细胞作为胰腺导管肿瘤的一个组成部分。I. 实验研究：包括胰岛细胞前体在内的导管细胞作为肿瘤的主要祖细胞。
Am J Pathol. 1978 Feb;90(2):295-316.
10
Early lesions of pancreatic ductal carcinoma in the hamster model.仓鼠模型中胰腺导管癌的早期病变
Am J Pathol. 1977 Aug;88(2):291-308.