Pour P, Althoff J, Takahashi M
Am J Pathol. 1977 Aug;88(2):291-308.
Syrian golden hamsters were treated weekly with 10 mg/kg body weight N-nitrosobis (2-oxopropyl) amine for life (Group 1) or 6 weeks and were sacrificed at biweekly intervals from 2 weeks (Group 1) and 8 weeks (Group 2) after initiation of the experiment. The pancreas was examined in step sections, and the sequential alterations noted for each interval were recorded. Lesions were found in intrapancreatic and extrapancreatic ducts. Equivalent alterations consisting of hyperplasia, metaplasia, atypia, and lesions characteristic of carcinoma in situ developed ubiquitously and simultaneously in pancreatic ducts of different sizes and in ductules, but not in acinar cells. Among the most significant findings were intrainsular ductular formations, their proliferation, and sequential malignant alteration comparable to the involved preexisting ductules. Differences between the two experimental groups were of a quantitative rather than qualitative nature. The incidence and multiplicity of neoplastic lesions at each interval according to group, sex, and anatomic locations of adenocarcinomas are outlined. Predilected areas for some lesions were found. Results indicate a common origin of all induced tumors from a pluripotent cell populating the pancreatic ductal system.
叙利亚金黄地鼠终身每周接受10毫克/千克体重的N-亚硝基双（2-氧代丙基）胺处理（第1组），或接受6周处理，并在实验开始后从第2周（第1组）和第8周（第2组）开始每两周处死一批。对胰腺进行连续切片检查，并记录每个时间间隔观察到的连续变化。在胰腺内和胰腺外导管中发现了病变。不同大小的胰腺导管和小导管中普遍同时出现了由增生、化生、异型性和原位癌特征性病变组成的等效改变，但腺泡细胞中未出现。其中最显著的发现是胰岛内导管形成、其增殖以及与受累的原有小导管相当的连续恶性改变。两个实验组之间的差异是数量上而非质量上的。概述了每个时间间隔根据组、性别和腺癌解剖位置的肿瘤性病变的发生率和多发性。发现了一些病变的好发部位。结果表明，所有诱导肿瘤均起源于构成胰腺导管系统的多能细胞。
