Akkary S, Sahwy E, Kandil W, Hamdy M H
J Pediatr Surg. 1981 Oct;16(5):664-8. doi: 10.1016/s0022-3468(81)80547-7.
From the histochemical studies of the mucus factor in normal controls and 10 cases with Hirschsprung's disease including 5 with enterocolitis, using Alcian blue-PAS method, we concluded that ganglionosis had no effect on the secretion of mucus. The presence of qualitative changes in the type of mucopolysaccharides, demonstrated as an increase in the sulphated group especially in cases with enterocolitis, was secondary to the chronic obstruction. These nonspecific changes might diminish the protecting mechanism of the mucous membrane. Quantitative changes were seen to be related to the severity of the enterocolitis.
通过采用阿尔辛蓝-过碘酸希夫（Alcian blue-PAS）法，对正常对照者以及10例先天性巨结肠患者（其中5例患有小肠结肠炎）的黏液因子进行组织化学研究，我们得出结论：神经节细胞症对黏液分泌没有影响。黏多糖类型的定性变化表现为硫酸化基团增加，尤其是在小肠结肠炎患者中，这种变化是慢性梗阻的继发结果。这些非特异性变化可能会削弱黏膜的保护机制。定量变化与小肠结肠炎的严重程度相关。
