Upadhyay R, Samiyeh R, Tafazuli A
Neoplasma. 1981;28(5):555-8.
The mouse ear irritant latex of E. virgata, has been found to contain various skin irritant and non-irritant esters of the diterpene ingenol. In cocarcinogenic assay on dorsal back skin of NMRI mice, acetone extract of this latex produces squamous cell papilloma. Using a combination of biologic and chemical separation techniques one of the initiator-promotor for skin carcinogenesis has been identified as 3-0-2 methyl-decanoyl ingenol.
已发现长梗卫矛的小鼠耳部刺激性乳胶含有二萜大戟醇的多种皮肤刺激性和非刺激性酯类。在对NMRI小鼠背部皮肤进行的促癌试验中，这种乳胶的丙酮提取物会产生鳞状细胞乳头瘤。通过结合生物学和化学分离技术，已确定一种皮肤致癌的引发剂-促癌剂为3-0-2-甲基癸酰大戟醇。
