Sanders M, White F C, Peterson T M, Bloor C M
Am J Physiol. 1978 May;234(5):H614-9. doi: 10.1152/ajpheart.1978.234.5.H614.
Coronary collateral blood flow was measured in 7 miniature pigs, exercise trained (ET) for 10 mo by running about 35 km/wk, and in 10 sedentary control pigs (SC). In acute, open-chest preparations, radiolabeled (85SR, 141CE, or 51Cr) microspheres, 15 +/- 5 micron in diameter, were injected into the left atrium during each of three conditions: control (C), total occlusion of the left circumflex artery (TO), and TO plus mechanically elevated aortic pressure (TOP). Blood flow to the circumflex bed during control condition in ET and SC was 0.36 +/- 0.07 (SE) and 0.43 +/- 0.10 ml.g-1.min-1, respectively. During TO, circumflex flow in ET and SC fell to 0.05 +/- 0.01 and 0.06 +/- 0.01 ml.g-1.min-1, respectively. In the presence of TOP, left circumflex flow in ET and SC rose to 0.11 +/- 0.04 and 0.11 +/- 0.02 ml.g-1.min-1, respectively. Blood flow to the tissue bed of the left anterior descendens was the same in both groups of pigs under all conditions. Thus, 10 mo of endurance exercise training seems to have no effect on the development of coronary collaterals in the left ventricles of pig hearts.
对7只小型猪进行了冠状动脉侧支血流测量，这些猪通过每周约35公里的跑步进行了10个月的运动训练（ET），并与10只久坐不动的对照猪（SC）进行比较。在急性开胸准备中，直径为15±5微米的放射性标记（85SR、141CE或51Cr）微球在三种情况下分别注入左心房：对照（C）、左旋支动脉完全闭塞（TO）以及TO加机械性升高主动脉压（TOP）。在对照条件下，ET组和SC组左旋支床的血流分别为0.36±0.07（SE）和0.43±0.10毫升·克-1·分钟-1。在TO期间，ET组和SC组的左旋支血流分别降至0.05±0.01和0.06±0.01毫升·克-1·分钟-1。在TOP存在的情况下，ET组和SC组的左旋支血流分别升至0.11±0.04和0.11±0.02毫升·克-1·分钟-1。在所有条件下，两组猪左前降支组织床的血流相同。因此，10个月的耐力运动训练似乎对猪心脏左心室冠状动脉侧支的发育没有影响。
