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亨廷顿舞蹈症:患者及其后代视觉与躯体感觉皮层诱发电位的改变

Huntington's disease: alterations of visual and somatosensory cortical evoked potentials in patients and offspring.

作者信息

Oepen G, Doerr M, Thoden U

出版信息

Adv Neurol. 1982;32:141-7.

PMID:6459718
Abstract

In 13 patients suffering form Huntington's chorea (H.Ch.), VEPs and SEPs were investigated in comparison to 9 clinically inconspicuous offspring and normal adults. 1. The mean amplitude of VEP was reduced in choreatic patients and in four out of nine offspring. 2. Latencies of P100 in VEP were normal in all subjects. 3. The late components were reduced in amplitude and rather irregular in shape. 4. The latencies of SEPs were slightly prolonged, less marked in the early peaks and more pronounced in the later ones. 5. The late components after 70 to 100 msec were often attenuated or even absent. 6. The mean amplitude of the first two peaks was reduced. 7. Interhemispheric asymmetries were pronounced in three out of nine offspring.

摘要

对13例患有亨廷顿舞蹈症(H.Ch.)的患者进行了视觉诱发电位(VEP)和体感诱发电位(SEP)研究,并与9例临床上无症状的后代及正常成年人进行了比较。1. 舞蹈症患者及9例后代中的4例VEP平均波幅降低。2. 所有受试者VEP中P100的潜伏期均正常。3. 晚成分波幅降低且形状相当不规则。4. SEP潜伏期略有延长,早期波峰处不太明显,后期波峰处更明显。5. 70至100毫秒后的晚成分常减弱甚至消失。6. 前两个波峰的平均波幅降低。7. 9例后代中有3例半球间不对称明显。

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Huntington's disease: alterations of visual and somatosensory cortical evoked potentials in patients and offspring.亨廷顿舞蹈症:患者及其后代视觉与躯体感觉皮层诱发电位的改变
Adv Neurol. 1982;32:141-7.
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