Steward M W
Clin Exp Immunol. 1979 Dec;38(3):414-23.
Two lines of mice selectively bred for producing high and low affinity antibody to protein antigens were repeatedly injected with human serum albumin and the severity and pattern of immune complex disease induced in this way was studied in the two lines. In low affinity mice, there was a greater intensity of deposits in the glomeruli shown by immunofluorescence, and more antibody was eluted from kidney homogenates compared to high affinity line mice. In the low affinity mice, complexes were mainly on the basement membrane whereas in high affinity mice, the localization of immune complexes was predominantly mesangial. However, no significant difference in glomerular filtration rates between the two lines was obtained. The immunopathological significance of antibody affinity is discussed in the light of these results.
对两组经选择性培育以产生针对蛋白质抗原的高亲和力和低亲和力抗体的小鼠，反复注射人血清白蛋白，并研究以此方式诱导的免疫复合物疾病在两组小鼠中的严重程度和模式。与高亲和力品系小鼠相比，低亲和力小鼠肾小球中免疫荧光显示的沉积物强度更大，且从肾匀浆中洗脱的抗体更多。在低亲和力小鼠中，复合物主要位于基底膜，而在高亲和力小鼠中，免疫复合物的定位主要在系膜区。然而，两组小鼠的肾小球滤过率未发现显著差异。根据这些结果讨论了抗体亲和力的免疫病理学意义。
