Verghese M W, Ward F E, Eisenbarth G S
Hum Immunol. 1981 Oct;3(2):173-9. doi: 10.1016/0198-8859(81)90054-9.
The Con-A--activated suppressor function of lymphocytes from polyglandular failure (PGF) patients in human mixed lymphocyte culture was compared to a normal population. As a group, PGF patients were found to have decreased suppressor activity: 67% of normal for autologous suppression, 45% of normal for heterologous. However, lymphocytes from most PGF patients have neither an absolute lack of suppressor activity nor an absolute inability to respond to suppression. The marked variability of assayed suppression, depending on the combination of stimulators and responder cells tested, limit the utility of this assay in defining individuals with abnormal suppressor function. One patient's lymphocytes were unique in that although suppression of heterologous cells was normal, suppression of her own cells was defective. Defective suppressor function may be related to the susceptibility of these patients to multiple autoimmune diseases.
将多腺体功能衰竭（PGF）患者淋巴细胞在人混合淋巴细胞培养中经刀豆蛋白A激活后的抑制功能与正常人群进行了比较。作为一个群体，PGF患者被发现抑制活性降低：自体抑制为正常水平的67%，异源抑制为正常水平的45%。然而，大多数PGF患者的淋巴细胞既没有绝对缺乏抑制活性，也没有绝对无法对抑制作出反应。所检测的抑制作用存在显著变异性，这取决于所测试的刺激细胞和反应细胞的组合，限制了该检测方法在定义具有异常抑制功能个体方面的实用性。一名患者的淋巴细胞很独特，尽管对异源细胞的抑制正常，但对其自身细胞的抑制存在缺陷。抑制功能缺陷可能与这些患者易患多种自身免疫性疾病有关。
