Astrup L B, Morling N, Ryder L P, Friis J, Pedersen F K, Svejgaard A
Scand J Immunol. 1982 Nov;16(5):361-7. doi: 10.1111/j.1365-3083.1982.tb00736.x.
Concanavalin-A-induced suppressor cell activity was investigated in 63 patients with a definite diagnosis of juvenile rheumatoid arthritis. Peripheral blood lymphoid cells from these patients did not have the same ability as cells from normal individuals to suppress the proliferative response of autologous cells, responding to phytohaemaglutinin, Candida albicans antigen, or allogeneic cells. No correlation was found between suppressor activity, disease activity, or number of joints involved. Nor was there any significant association between decreased suppressor cell activity and HLA-A, -B, -C, -D antigens, although there was a tendency towards association between decreased suppressor cell activity and HLA-B27.
对63例确诊为幼年类风湿性关节炎的患者研究了刀豆球蛋白A诱导的抑制细胞活性。这些患者的外周血淋巴细胞与正常个体的细胞相比，抑制自体细胞对植物血凝素、白色念珠菌抗原或同种异体细胞增殖反应的能力不同。在抑制活性、疾病活动度或受累关节数量之间未发现相关性。抑制细胞活性降低与HLA - A、- B、- C、- D抗原之间也无显著关联，不过抑制细胞活性降低与HLA - B27之间有一定的关联倾向。
