• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

DNA strand breaks in pancreatic islets by in vivo administration of alloxan or streptozotocin.

作者信息

Yamamoto H, Uchigata Y, Okamoto H

出版信息

Biochem Biophys Res Commun. 1981 Dec 15;103(3):1014-20. doi: 10.1016/0006-291x(81)90910-4.

DOI:10.1016/0006-291x(81)90910-4
PMID:6460502
Abstract
摘要

相似文献

1
DNA strand breaks in pancreatic islets by in vivo administration of alloxan or streptozotocin.
Biochem Biophys Res Commun. 1981 Dec 15;103(3):1014-20. doi: 10.1016/0006-291x(81)90910-4.
2
DNA strand breaks and poly(ADP-ribose) synthetase activation in pancreatic islets--a new aspect to development of insulin-dependent diabetes and pancreatic B-cell tumors.胰岛中的DNA链断裂与聚（ADP-核糖）合成酶激活——胰岛素依赖型糖尿病和胰腺β细胞瘤发生发展的新视角
Princess Takamatsu Symp. 1983;13:297-308.
3
Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets.
Nature. 1981 Nov 19;294(5838):284-6. doi: 10.1038/294284a0.
4
[Structural and enzymatic changes in the islets of the rat pancreas following alloxan and streptozotocin administration].[注射四氧嘧啶和链脲佐菌素后大鼠胰腺胰岛的结构及酶变化]
Cell Mol Biol Incl Cyto Enzymol. 1978;23(4):355-67.
5
Chemiluminescence as an index of drug-induced free radical production in pancreatic islets.化学发光作为胰岛中药物诱导自由基产生的指标。
Diabetes. 1984 Feb;33(2):160-3. doi: 10.2337/diab.33.2.160.
6
Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis.超氧化物歧化酶、过氧化氢酶和聚（ADP - 核糖）合成酶抑制剂对四氧嘧啶和链脲佐菌素诱导的胰岛DNA链断裂以及对胰岛素原合成抑制的保护作用。
J Biol Chem. 1982 Jun 10;257(11):6084-8.
7
Streptozocin- and alloxan-induced H2O2 generation and DNA fragmentation in pancreatic islets. H2O2 as mediator for DNA fragmentation.链脲佐菌素和四氧嘧啶诱导胰岛中过氧化氢的产生及DNA片段化。过氧化氢作为DNA片段化的介质。
Diabetes. 1991 Sep;40(9):1141-5. doi: 10.2337/diab.40.9.1141.
8
Alloxan-induced DNA strand breaks in pancreatic islets. Evidence for H2O2 as an intermediate.
J Biol Chem. 1991 Feb 5;266(4):2112-4.
9
Streptozotocin, but not alloxan, induces DNA repair synthesis in mouse pancreatic islets in vitro.链脲佐菌素而非四氧嘧啶可在体外诱导小鼠胰岛中的DNA修复合成。
Diabetologia. 1983 Nov;25(5):444-7. doi: 10.1007/BF00282526.
10
The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.四氧嘧啶和链脲佐菌素对大鼠胰腺B细胞的作用机制。
Physiol Res. 2001;50(6):537-46.

引用本文的文献

1
Okamoto model for necrosis and its expansions, CD38-cyclic ADP-ribose signal system for intracellular Ca mobilization and Reg (Regenerating gene protein)-Reg receptor system for cell regeneration.冈本模型的坏死及其扩展、CD38-cyclic ADP-ribose 信号系统用于细胞内 Ca 动员，以及 Reg（再生基因蛋白）-Reg 受体系统用于细胞再生。
Proc Jpn Acad Ser B Phys Biol Sci. 2021;97(8):423-461. doi: 10.2183/pjab.97.022.
2
Regulated Cell Death Seen through the Lens of Islet Transplantation.通过胰岛移植看细胞程序性死亡。
Cell Transplant. 2018 Jun;27(6):890-901. doi: 10.1177/0963689718766323. Epub 2018 May 30.
3
Oxidative damage of DNA induced by the reaction of methylglyoxal with lysine in the presence of ferritin.
铁蛋白存在时，由甲基乙二醛与赖氨酸反应引起的 DNA 氧化损伤。
BMB Rep. 2013 Apr;46(4):225-9. doi: 10.5483/bmbrep.2013.46.4.225.
4
Cytokine-mediated β-cell damage in PARP-1-deficient islets.PARP-1 缺陷胰岛细胞中细胞因子介导的β细胞损伤。
Am J Physiol Endocrinol Metab. 2012 Jul 15;303(2):E172-9. doi: 10.1152/ajpendo.00055.2012. Epub 2012 Apr 24.
5
CD38 autoimmunity: recent advances and relevance to human diabetes.CD38自身免疫：最新进展及其与人类糖尿病的关联
J Endocrinol Invest. 2004 Jul-Aug;27(7):695-707. doi: 10.1007/BF03347507.
6
Nitric oxide generation and poly(ADP ribose) polymerase activation precede beta-cell death in rats with a single high-dose injection of streptozotocin.单次高剂量注射链脲佐菌素的大鼠中，一氧化氮生成和聚（ADP核糖）聚合酶激活先于β细胞死亡。
Virchows Arch. 2004 Apr;444(4):375-82. doi: 10.1007/s00428-003-0967-z. Epub 2004 Feb 4.
7
Induction of islet B-cell regeneration in partially pancreatectomized rats by poly(ADP-ribose) synthetase inhibitors.聚（ADP-核糖）合成酶抑制剂诱导部分胰腺切除大鼠胰岛B细胞再生
Int J Pancreatol. 1988 Jan-Feb;3(1):73-82. doi: 10.1007/BF02788225.
8
A single major gene controls most of the difference in susceptibility to streptozotocin-induced diabetes between C57BL/6J and C3H/HeJ mice.一个主要基因控制着C57BL/6J小鼠和C3H/HeJ小鼠对链脲佐菌素诱导糖尿病易感性的大部分差异。
Diabetologia. 1989 Oct;32(10):716-23. doi: 10.1007/BF00274530.
9
The immunocytochemical localization of superoxide dismutase in the enterocytes of the avian intestine: the effect of vitamin D3.超氧化物歧化酶在禽类肠道肠细胞中的免疫细胞化学定位：维生素D3的作用
Histochem J. 1989 Apr;21(4):194-202. doi: 10.1007/BF01747520.
10
Effect of nicotinamide therapy upon B-cell function in newly diagnosed type 1 (insulin-dependent) diabetic patients.烟酰胺疗法对新诊断的1型（胰岛素依赖型）糖尿病患者B细胞功能的影响。
Diabetologia. 1989 Mar;32(3):160-2. doi: 10.1007/BF00265087.