Maddox J F, Mackay C R, Brandon M R
Immunology. 1985 Jun;55(2):347-53.
The tissue distribution and immunochemical properties of antigens recognized by two monoclonal antibodies 1.11.32 and 1.28.124 define the sheep analogue of the leucocyte common antigen found in rat, man and mouse. Histological and immunofluorescent studies show that this antigen is found on all lymphocytes, as well as other leucocytes but is absent from non-leucocytic cells. Immunochemical data show that a series of proteins of high molecular weight (190,000-225,000) are recognized, and histological studies show the presence of this antigen on a subpopulation of fetal liver cells as early as Day 27-30 of gestation, and on all fetal thymocytes from Day 40 of gestation.
两种单克隆抗体1.11.32和1.28.124所识别抗原的组织分布和免疫化学特性确定了在大鼠、人和小鼠中发现的白细胞共同抗原的绵羊类似物。组织学和免疫荧光研究表明,这种抗原存在于所有淋巴细胞以及其他白细胞上,但不存在于非白细胞细胞中。免疫化学数据表明,可识别一系列高分子量(190,000 - 225,000)的蛋白质,组织学研究表明,早在妊娠第27 - 30天,这种抗原就存在于胎儿肝细胞的一个亚群上,从妊娠第40天起存在于所有胎儿胸腺细胞上。