Lehmann-Grube F, Cihak J, Varho M, Tijerina R
J Gen Virol. 1982 Feb;58(Pt 2):223-35. doi: 10.1099/0022-1317-58-2-223.
Infection of CBA/J mice with low doses of strain WE lymphocytic choriomeningitis (LCM) virus resulted in high cell-mediated and relatively low humoral virus-specific immune phenomena; anamnestic responses were marked. In contrast, infection with high doses of this virus induced no or low degrees of cell-mediated immune phenomena but higher antibody concentrations. Subsequent challenge of these mice did not reveal cell-mediated immunity. However, transfer of spleen cells from mice suppressed as to cell-mediated immunity together with virus into X-irradiated recipients led to marked anamnestic responses. Furthermore, when spleen cells from mice previously infected with low virus doses were injected into mice previously infected with high virus doses, cell-mediated immune phenomena could not be induced by concomitantly inoculated virus, although in controls anamnestic responses were readily evoked. Thus, infection with high doses of LCM virus actively suppressed LCM virus-specific cell-mediated immune responses but led to increased production of antibodies. suppressor cells could not be demonstrated.
用低剂量的WE株淋巴细胞性脉络丛脑膜炎（LCM）病毒感染CBA/J小鼠，会导致强烈的细胞介导免疫现象以及相对较弱的体液病毒特异性免疫现象；记忆反应很明显。相比之下，用高剂量的这种病毒感染则不会诱导或仅诱导低程度的细胞介导免疫现象，但会产生更高的抗体浓度。对这些小鼠进行后续攻击并未显示出细胞介导免疫。然而，将细胞介导免疫受到抑制的小鼠的脾细胞与病毒一起转移到经X射线照射的受体中，会导致明显的记忆反应。此外，当将先前用低剂量病毒感染的小鼠的脾细胞注射到先前用高剂量病毒感染的小鼠中时，尽管在对照中很容易引发记忆反应，但同时接种的病毒无法诱导细胞介导免疫现象。因此，用高剂量的LCM病毒感染会积极抑制LCM病毒特异性细胞介导免疫反应，但会导致抗体产生增加。未证明存在抑制细胞。
