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Rac-大肠杆菌K12菌株携带λ rev的优先附着位点。

Rac-E. coli K12 strains carry a preferential attachment site for lambda rev.

作者信息

Diaz R, Kaiser K

出版信息

Mol Gen Genet. 1981;183(3):484-9. doi: 10.1007/BF00268769.

DOI:10.1007/BF00268769
PMID:6460911
Abstract

Lambda rev is a hybrid lambdoid phage formed by recombination between lambda and a defective lambdoid prophage (Rac) present in most E. coli K12 derivatives. We show here that three independently derived Rac-E. coli K12 strains are specifically deleted for the entire Rac prophage consistent with loss of Rac by excisive recombination between hybrid attachment sites that flank the prophage (c.f. excision of a lambda prophage). lambda rev, in which int and PP' of lambda have been replaced by integrative recombination genes and an attachment site derived from Rac (Gottesman et al. 1974), integrates site-specifically and in the correct orientation at the preferential attachment site generated by Rac excision.

摘要

λrev是一种混合λ样噬菌体，由λ与大多数大肠杆菌K12衍生物中存在的缺陷λ样原噬菌体（Rac）之间的重组形成。我们在此表明，三个独立衍生的Rac-大肠杆菌K12菌株中，整个Rac原噬菌体被特异性删除，这与原噬菌体两侧的杂种附着位点之间通过切除性重组导致Rac丢失一致（参见λ原噬菌体的切除）。λrev中，λ的int和PP'已被整合重组基因和源自Rac的附着位点取代（戈特斯曼等人，1974年），它在Rac切除产生的优先附着位点上进行位点特异性且方向正确的整合。

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1
Rac-E. coli K12 strains carry a preferential attachment site for lambda rev.Rac-大肠杆菌K12菌株携带λ rev的优先附着位点。
Mol Gen Genet. 1981;183(3):484-9. doi: 10.1007/BF00268769.
2
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引用本文的文献

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2
Linkage map of Escherichia coli K-12, edition 7.大肠杆菌K-12连锁图谱，第7版。
Microbiol Rev. 1983 Jun;47(2):180-230. doi: 10.1128/mr.47.2.180-230.1983.
3
Zygotic induction of the rac locus can cause cell death in E. coli.rac基因座的合子诱导可导致大肠杆菌细胞死亡。

本文引用的文献

1
Sensitive mutants of bacteriophage lambda.噬菌体λ的敏感突变体
Virology. 1961 May;14:22-32. doi: 10.1016/0042-6822(61)90128-3.
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Linkage map of Escherichia coli K-12, edition 6.大肠杆菌K-12连锁图谱，第6版。
Microbiol Rev. 1980 Mar;44(1):1-56. doi: 10.1128/mr.44.1.1-56.1980.
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On the nature of sbcA mutations in E. coli K 12.关于大肠杆菌K12中sbcA突变的性质
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4
Inhibition of replication forks exiting the terminus region of the Escherichia coli chromosome occurs at two loci separated by 5 min.抑制从大肠杆菌染色体末端区域退出的复制叉发生在两个相隔5分钟的位点。
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Integration of bacteriophage lambda into the cryptic lambdoid prophages of Escherichia coli.噬菌体λ整合到大肠杆菌的隐蔽类λ原噬菌体中。
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The origin of Q-independent derivatives of phage lambda.噬菌体λ的Q非依赖型衍生物的起源
Mol Gen Genet. 1980;179(3):547-54. doi: 10.1007/BF00271744.
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New mutations in the S cistron of bacteriophage lambda affecting host cell lysis.噬菌体λ S顺反子中影响宿主细胞裂解的新突变。
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Abortive induction of bacteriophage P2.噬菌体P2的流产诱导
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7
Characterization of bacteriophage lambda reverse as an Escherichia coli phage carrying a unique set of host-derived recombination functions.将噬菌体λ反向鉴定为携带一组独特的宿主衍生重组功能的大肠杆菌噬菌体。
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8
The segregation of the SbcA and Rac phenotypes in an Escherichia coli recB mutant.大肠杆菌recB突变体中SbcA和Rac表型的分离
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9
Restoration by the rac locus of recombinant forming ability in recB - and recC - merozygotes of Escherichia coli K-12.大肠杆菌K-12的recB - 和recC - 部分二倍体中rac位点对重组形成能力的恢复作用
Mol Gen Genet. 1973 Apr 12;122(2):119-30. doi: 10.1007/BF00435185.
10
Prophage lambda at unusual chromosomal locations. I. Location of the secondary attachment sites and the properties of the lysogens.处于异常染色体位置的λ原噬菌体。I. 二级附着位点的定位及溶原菌的特性
J Mol Biol. 1972 Feb 14;63(3):483-503. doi: 10.1016/0022-2836(72)90443-3.