Termijtelen A, Meera Khan P, Shaw S, van Rood J J
Immunogenetics. 1983;18(5):503-12. doi: 10.1007/BF00364391.
A newly defined leukocyte antigen system, the secondary B-cell (SB) system, was shown to be linked to HLA. The SB marker has been investigated in lymphocyte donors presumed to be genetically homozygous for HLA-A through HLA-D/DR by virtue of descent from a first-cousin marriage and of phenotypic homozygosity for these HLA markers. Of 19 donors, 3 were found to be heterozygous for SB. Studies of the families of these three donors could not distinguish with certainty whether the heterozygosity resulted from SB/DR recombination or from "pseudohomozygosity" for HLA-A through -D/DR by inheritance of two genetically unrelated but similar haplotypes. However, our data favored the occurrence of SB/DR recombination with a meiotic distance perhaps as large as 3.3 cMorgan. Recombinations were identified which mapped SB between HLA-B and GLO1. These studies demonstrate the usefulness of cells from first-cousin marriage offspring in mapping a polymorphic genetic system.
一种新定义的白细胞抗原系统，即二级B细胞（SB）系统，被证明与HLA相关联。通过一级表亲婚姻的后代以及这些HLA标记的表型纯合性，对被认为在HLA - A至HLA - D/DR方面基因纯合的淋巴细胞供体中的SB标记进行了研究。在19名供体中，发现3名SB为杂合子。对这三名供体的家族研究无法确定地分辨出这种杂合性是由SB/DR重组导致的，还是由于通过遗传两个基因上不相关但相似的单倍型而在HLA - A至 - D/DR方面出现“假纯合性”。然而，我们的数据支持SB/DR重组的发生，其减数分裂距离可能高达3.3厘摩。已鉴定出重组事件，这些重组事件将SB定位在HLA - B和GLO1之间。这些研究证明了一级表亲婚姻后代的细胞在绘制多态遗传系统图谱中的有用性。
