恒河猴实验性免疫介导性关节炎。人类类风湿关节炎的一种模型？
Experimental immune mediated arthritis in rhesus monkeys. A model for human rheumatoid arthritis?
作者信息
Bakker N P, van Erck M G, Zurcher C, Faaber P, Lemmens A, Hazenberg M, Bontrop R E, Jonker M
机构信息
TNO Primate Center, Rijswijk, The Netherlands.
出版信息
Rheumatol Int. 1990;10(1):21-9. doi: 10.1007/BF02274777.
The induction of experimental arthritis in rhesus monkeys was studied by intradermal immunization of bovine type II collagen and antigens derived from Mycobacterium tuberculosis, Streptococcus pyogenes, and Eubacterium aerofaciens. The tested bacterial antigens proved to be not arthrogenic. Bovine type II collagen induced clinical arthritis in 50% of the rhesus monkeys. Type II collagen induced arthritis in rhesus monkeys proved to be a potential model to study clinical, serological, histological, genetic, and immunologic features associated with human RA.
通过对恒河猴进行皮内免疫牛II型胶原蛋白以及来源于结核分枝杆菌、化脓性链球菌和气肿真杆菌的抗原，研究了实验性关节炎的诱导情况。经测试，所使用的细菌抗原不具有致关节炎性。牛II型胶原蛋白在50%的恒河猴中诱发了临床关节炎。在恒河猴中由II型胶原蛋白诱发的关节炎被证明是一种研究与人类类风湿性关节炎相关的临床、血清学、组织学、遗传学和免疫学特征的潜在模型。
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