Sheth K J, Thomas J P
J Electrocardiol. 1982 Apr;15(2):153-6. doi: 10.1016/s0022-0736(82)80010-1.
We studied the ECGs of 47 kindred members from three families with Fabry's disease. The control group (19) with normal plasma alpha-galactosidase levels had normal ECGs. Of the 12 affected males (mean age 15 years, plasma alpha-galactosidase levels less than 10% of normals), ten had ECG evidence of LVH, and five had ST-T wave changes. The conduction time of the cardiac impulse was accelerated (decreased PR index) in one male. Of the 16 heterozygous females (mean age 19 years, plasma alpha-galactosidase level and alpha/beta galactosidase ratio in the carrier range) none had ECG evidence of LVH, but six had conduction abnormalities--decreased PR index (four) and delayed conduction (two). The ECG abnormalities were uniformly distributed in different age groups.
我们研究了来自三个患有法布里病家族的47名亲属的心电图。血浆α-半乳糖苷酶水平正常的对照组（19人）心电图正常。12名受影响男性（平均年龄15岁，血浆α-半乳糖苷酶水平低于正常水平的10%）中，10人有左心室肥厚的心电图证据，5人有ST-T波改变。一名男性的心脏冲动传导时间加快（PR指数降低）。16名杂合子女性（平均年龄19岁，血浆α-半乳糖苷酶水平和α/β半乳糖苷酶比率在携带者范围内）均无左心室肥厚的心电图证据，但6人有传导异常——PR指数降低（4人）和传导延迟（2人）。心电图异常在不同年龄组中分布均匀。
