Nonspecific human lymphocyte-mediated cytotoxicity induced by immobilized IgG aggregate: regulation by suppressor cells.

Normal human lymphocytes lyse a variety of erythrocytes when effector cells and target cells are incubated on immobilized, normal human IgG aggregates (10). Lymphocyte-mediated cytolysis induced by immobilized aggregate requires an overnight incubation with adherent mononuclear cells. This study was carried out to determine whether preincubation with adherent cells effects the activation of a cytolytic cell or inactivation of a suppressor cell. It was determined that a suppressor cell function is inactivated, and the suppressor cells were characterized as T gamma and T mu lymphocytes.