携带IgG和IgM Fc受体的人T淋巴细胞亚群的MICC细胞毒性效应功能。
MICC cytotoxic effector function of human T lymphocyte subpopulations bearing Fc-receptors for IgG and IgM.
作者信息
Lum L G, Muchmore A V, Decker J M, Blaese R M
出版信息
Clin Exp Immunol. 1979 Sep;37(3):558-61.
Purified subpopulations of human T lymphocytes bearing Fc-IgG and Fc-IgM receptors were studied for their ability to mediate mitogen (PHA) induced cellular cytotoxicity (MICC) to chicken erythrocyte (CRBC) and DBA/Mastocytoma P815Y tumour cell targets. There were marked differences in the ability of the Fc-IgG receptor-bearing T cell (T gamma) and the Fc-IgM (T mu) to mediating MICC to CRBC and P815Y target cells. T gamma cells were very efficient killers of CRBC and T mu cells had no cytotoxic activity to CRBC. On the other hand, both the T gamma and T mu subpopulations were able to mediate MICC to P815Y tumour cell targets.
对携带Fc-IgG和Fc-IgM受体的人T淋巴细胞纯化亚群进行了研究，以考察它们介导丝裂原（PHA）诱导的对鸡红细胞（CRBC）和DBA/肥大细胞瘤P815Y肿瘤细胞靶标的细胞毒性（MICC）的能力。携带Fc-IgG受体的T细胞（Tγ）和Fc-IgM（Tμ）介导对CRBC和P815Y靶细胞的MICC的能力存在显著差异。Tγ细胞是CRBC的高效杀伤细胞，而Tμ细胞对CRBC没有细胞毒性活性。另一方面，Tγ和Tμ亚群都能够介导对P815Y肿瘤细胞靶标的MICC。
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