Weitzner S
Am Surg. 1978 Apr;44(4):206-9.
Cases of 20 patients with adenoacenthoma of the pancreas with clinicopathologic data, including the four added, are reviewed. The clinical manifestations, sites of metastases, survival and gross pathology appear to be similar to the usual adenocarcinoma of the pancreas. Adenoacanthoma of the pancreas most probably represents squamous metaplasia of an adenocarcinoma or arises from an undifferentiated cell in the pancreatic duct system. The metastases are typically an admixture of both elements but in four cases, pure squamous or adenocarcinoma metastases were encountered. It is suggested that the pancreas should be included as a possible source in those patients with an unknown primary who have a metastasis consisting of either an admixture of squamous and glandular elements or a pure squamous type and in those instances in which a pure squamous and a pure adenocarcinoma are encountered in different metastases.
对20例胰腺腺棘皮瘤患者的病例进行回顾，包括新增的4例，同时分析其临床病理数据。临床表现、转移部位、生存率和大体病理表现似乎与常见的胰腺腺癌相似。胰腺腺棘皮瘤很可能代表腺癌的鳞状化生，或起源于胰腺导管系统中的未分化细胞。转移灶通常是两种成分的混合，但在4例中，发现了纯鳞状或腺癌转移灶。建议对于那些原发灶不明但转移灶由鳞状和腺性成分混合或纯鳞状类型组成的患者，以及在不同转移灶中出现纯鳞状和纯腺癌的情况，应将胰腺作为可能的原发部位纳入考虑。
