Tresch D D, Halverson G, Blick M, Keelan M H
Ann Intern Med. 1978 May;88(5):642-6. doi: 10.7326/0003-4819-88-5-642.
Corpus luteum hemorrhage is a complication of long-term anticoagulant therapy that has rarely been reported in the literature. Within 16 months, we saw six cases in which young women taking anticoagulants to prevent clotting of prosthetic heart valves suffered corpus luteum hemorrhages. Diagnosis was difficult and delayed. Medication stopped the bleeding in three patients; bilateral salpingo-oophorectomy was necessary in the remaining three. Our patients had great difficulty controlling their anticoagulant therapy and had histories of previous bleeding episodes. We believe corpus luteum hemorrhage may become more common as more premenopausal women undergo cardiac valvular surgery.
黄体出血是长期抗凝治疗的一种并发症，文献中鲜有报道。在16个月内，我们见到6例服用抗凝剂以防止人工心脏瓣膜凝血的年轻女性发生黄体出血。诊断困难且延迟。3例患者通过药物治疗止血；其余3例则需要进行双侧输卵管卵巢切除术。我们的患者在控制抗凝治疗方面存在很大困难，且有既往出血史。我们认为，随着越来越多的绝经前女性接受心脏瓣膜手术，黄体出血可能会变得更加常见。
