Loeper J, Emerit J, Goy J, Rozensztajn L, Fragny M
Pathol Biol (Paris). 1984 Jun;32(6):693-7.
Free fatty acids (FFA) and esterified fatty acids (EFA), lipid peroxidation were analysed in experimental atheroma. Among rabbits receiving cholesterol (formula; see text) compared with controls group in FFA and EFA on plasma and aortas: arachidonic acid in plasma and malonaldehyde (MDA) in plasma and aorta are increased with atheroma and there is a positive correlation between arachidonic acid, MDA, and arterial injury; organo silicic compounds when added to atherogenic diet, had a favorable action about these variations, organic silicon having an antiatheromatous action. Therefore it seems possible that unsaturated fatty acid's peroxidation had an injurious action on arteries in atheroma by discharging toxic endoperoxides; arachidonic acid is probably involved in thromboxane's generation, and consequently in aggregability of blood platelets.
在实验性动脉粥样硬化中分析了游离脂肪酸（FFA）、酯化脂肪酸（EFA）和脂质过氧化情况。在接受胆固醇的兔子（配方；见正文）中，与对照组相比，血浆和主动脉中的FFA和EFA：随着动脉粥样硬化的发展，血浆中的花生四烯酸以及血浆和主动脉中的丙二醛（MDA）增加，并且花生四烯酸、MDA与动脉损伤之间存在正相关；当将有机硅化合物添加到致动脉粥样硬化饮食中时，对这些变化具有有益作用，有机硅具有抗动脉粥样硬化作用。因此，不饱和脂肪酸的过氧化可能通过释放有毒的内过氧化物对动脉粥样硬化中的动脉产生有害作用；花生四烯酸可能参与血栓素的生成，进而参与血小板的聚集。
