Kwee M S, Stolk L M
Pharm Weekbl Sci. 1984 Jun 22;6(3):101-4. doi: 10.1007/BF01962998.
An injection fluid with vidarabine phosphate (37.5 mg/ml, pH 7.4) was formulated. After steam sterilization for 20 min at 120 degrees C a 6.1% degradation was observed. No significant (p greater than 0.05) degradation could be observed after heating in steam for 30 min at 100 degrees C and after storage for four months at 4 degrees C. From the results of an investigation of the degradation rate at elevated temperatures a negligible loss of content after a three years' storage period at 4 degrees C could be predicted.
配制了含磷酸阿糖腺苷（37.5毫克/毫升，pH值7.4）的注射液。在120℃蒸汽灭菌20分钟后，观察到有6.1%的降解。在100℃蒸汽中加热30分钟以及在4℃储存四个月后，未观察到显著（p大于0.05）降解。根据高温下降解速率的研究结果，可以预测在4℃储存三年后含量损失可忽略不计。
