免疫球蛋白基因恒定区和可变区之间的编码策略差异。
Coding strategy differences between constant and variable segments of immunoglobulin genes.
作者信息
Perrin P
出版信息
Nucleic Acids Res. 1984 Jul 11;12(13):5515-27. doi: 10.1093/nar/12.13.5515.
Abstract
Vertebrate immunoglobulin (Ig) mRNAs reveal intraspecies variation in codon usage distinct from that seen with yeast or bacterial genes. Comparison of all available Ig gene sequences shows that %(G + C) in codon position III is consistently lower in variable (V) segments than in constant (C) segments. I find an even lower %(G + C) in the hypervariable domains of V segments. This analysis suggests that base substitution in Ig genes correlates positively with local A + T content.
摘要
脊椎动物免疫球蛋白（Ig）mRNA显示出种内密码子使用的差异，这与酵母或细菌基因不同。对所有可用的Ig基因序列进行比较表明，密码子第三位的%（G + C）在可变（V）片段中始终低于恒定（C）片段。我发现在V片段的高变区中%（G + C）更低。该分析表明Ig基因中的碱基替换与局部A + T含量呈正相关。
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