Shillabeer G, Davison J S
Regul Pept. 1984 Apr;8(3):171-6. doi: 10.1016/0167-0115(84)90058-2.
Cholecystokinin, secreted in response to ingested food entering the duodenum, may play a role in limiting food intake. Inhibition of cholecystokinin should therefore induce an increase in food intake. Proglumide, a specific antagonist of cholecystokinin was used to block the satiety effect of a food preload in rats. A significant increase in food intake was obtained following proglumide injection, thus supporting the hypothesis that cholecystokinin, released by food in the duodenum, acts as a short-term satiety factor.
胆囊收缩素是在摄入的食物进入十二指肠时分泌的，它可能在限制食物摄入量方面发挥作用。因此，抑制胆囊收缩素应该会导致食物摄入量增加。丙谷胺是胆囊收缩素的一种特异性拮抗剂，被用于阻断大鼠食物预负荷的饱腹感效应。注射丙谷胺后食物摄入量显著增加，从而支持了这样一种假说，即十二指肠中的食物释放的胆囊收缩素作为一种短期饱腹感因子发挥作用。
