Effect of a single dose of T3 on the uptake of (2-14C)-ethanolamine into chicken liver phospholipids.

The effect of a single dose of 3,3',5-triidothyronine (T3) on the (2-14C)-ethanolamine uptake into liver phosphatidylethanolamine (PE) and lysophosphatidylethanolamine (LPE) were determined in chicken over a period of 0.25 to 6 h after radioactive precursor injection. In all cases animals received the T3 dose intraperitoneally 5 h before the injection of the labeled compound. T3 enhances the incorporation of (2-14C)-ethanolamine into liver PE and LPE. The maximum uptake takes place at 0.25 h for LPE and 0.5 h for PE after the precursor administration. A great and significant hormone-dependent increase in the incorporation of labeled compound is observed in LPE. Lipid P associated to PE and LPE remains constant throughout the experiment, and does not vary with hormone treatment. It is suggested that T3-injection increases, either directly or through other metabolic processes, PE and LPE turnover in chicken liver cells.