两性霉素B在人体内的药代动力学。
Amphotericin B pharmacokinetics in humans.
作者信息
Atkinson A J, Bennett J E
出版信息
Antimicrob Agents Chemother. 1978 Feb;13(2):271-6. doi: 10.1128/AAC.13.2.271.
Abstract
The pharmacokinetics of amphotericin B were studied in two patients at the conclusion of long-term therapy for disseminated histoplasmosis. The distribution kinetics of this drug were adequately described by a three-compartment mamillary model with a total distribution volume averaging 4 liters/kg. The elimination phase half-life of amphotericin B was approximately 15 days, reflecting slow release of amphotericin B from a peripheral compartment. In accordance with previous reports, renal excretion accounted for only 3% of total amphotericin B elimination. The pharmacokinetic model for one of the patients also was used to compare the simulated amphotericin B serum levels that would be expected if initial therapy followed two recommended regimens.
摘要
在两名播散性组织胞浆菌病患者长期治疗结束时，研究了两性霉素B的药代动力学。该药物的分布动力学可用三室乳头状模型充分描述，总分布容积平均为4升/千克。两性霉素B的消除相半衰期约为15天，反映了两性霉素B从外周室的缓慢释放。与先前的报告一致，肾排泄仅占两性霉素B总消除量的3%。其中一名患者的药代动力学模型还用于比较如果初始治疗遵循两种推荐方案预期的模拟两性霉素B血清水平。
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