Arlet P, Carré P, Bismuth J M, Larregain-Fournier D, Le Tallec Y
Rev Pneumol Clin. 1984;40(3):205-7.
A 69 year-old woman with no previous history of lung disease was treated with 500 mg of Amiodarone per week. After 21 months of treatment, she developed a clinical picture of alveolitis with fibrosis, which was confirmed by histological examination. No other drug known for its fibrotic properties had been administered. Treatment with Nifedipine and Isosorbide dinitrate had been prescribed prior to the Amiodarone. Simply stopping the Amiodarone led to a regression or disappearance of the clinical, radiological and functional signs. Immunological investigations revealed the presence of antinuclear antibodies and a positive lymphoblastic transformation test for the drug, which are the abnormalities that one finds in other types of drug-induced fibrosis (nitrofuradantin). A new finding was the presence of cutaneous immunofluorescence of granular deposits of IgG, IgM and complement at the dermo-epidermal junction. So far, there have been 13 cases of lung disease related to the administration of Amiodarone reported in the literature.
一名69岁、既往无肺部疾病史的女性患者，每周接受500毫克胺碘酮治疗。治疗21个月后，她出现了伴有纤维化的肺泡炎临床表现，经组织学检查得以证实。未使用过其他已知具有纤维化特性的药物。在使用胺碘酮之前，曾开具硝苯地平和硝酸异山梨酯进行治疗。单纯停用胺碘酮导致临床、放射学和功能体征消退或消失。免疫学检查发现存在抗核抗体以及针对该药物的淋巴细胞转化试验呈阳性，这些异常情况在其他类型的药物性纤维化（呋喃妥因）中也能发现。一项新发现是在真皮 - 表皮交界处存在IgG、IgM和补体颗粒状沉积物的皮肤免疫荧光。迄今为止，文献中已报道了13例与胺碘酮给药相关的肺部疾病病例。
