Mårtensson J, Sjödahl R, Tobiasson P
Scand J Gastroenterol. 1984 Jun;19(4):507-14.
The urinary excretion of sulfur amino acids and their main degradation products was determined in patients subjected to various forms of gastrointestinal surgery or with bacterial overgrowth. A normal excretion of total sulfur and inorganic sulfate was found, indicating an adequate intake and maintained ability to absorb sulfur amino acids. An increased excretion of ester sulfate was observed in all groups except patients subjected to ileocecal resection or proctocolectomy, probably owing to bacterial overgrowth. A reduced excretion of methionine was observed in patients with gastric resection (Billroth I), ileocecal resection, and abnormal gut flora, whereas patients with jejunoileal bypass showed an increased excretion of methionine, probably a consequence of the impaired liver function. For cystathionine, a similar effect was found in patients with ileocecal resection and jejunoileal bypass. A reduced excretion of mercaptolactate was found in jejunoileal bypass patients. A low excretion of thiosulfate was seen in proctocolectomized patients, suggesting that the bacterial flora of the colon plays a role in the formation of thiosulfate. A low excretion of thiocyanate was found in gastric-resected patients, which may be due to a decreased ability to hydrolyze cyanogenic and/or thiocyanogenic glycosides or to a reduced intake of these compounds.
对接受各种形式胃肠手术或存在细菌过度生长的患者，测定了含硫氨基酸及其主要降解产物的尿排泄情况。发现总硫和无机硫酸盐的排泄正常，表明硫氨基酸的摄入量充足且吸收能力维持良好。除回盲部切除术或直肠结肠切除术患者外，所有组均观察到硫酸酯排泄增加，这可能是由于细菌过度生长所致。胃切除术（毕罗一世式）、回盲部切除术及肠道菌群异常的患者，蛋氨酸排泄减少；而空肠回肠旁路术患者蛋氨酸排泄增加，这可能是肝功能受损的结果。对于胱硫醚，回盲部切除术和空肠回肠旁路术患者也有类似情况。空肠回肠旁路术患者巯基乳酸排泄减少。直肠结肠切除术后患者硫代硫酸盐排泄量低，提示结肠菌群在硫代硫酸盐形成中起作用。胃切除患者硫氰酸盐排泄量低，这可能是由于水解含氰和/或硫氰糖苷的能力下降或这些化合物摄入量减少所致。
