一名严重缺乏凝血因子XII且患有心肌梗死的患者存在内源性纤维蛋白溶解活性缺陷。
Defective intrinsic fibrinolytic activity in a patient with severe factor XII-deficiency and myocardial infarction.
作者信息
Lodi S, Isa L, Pollini E, Bravo A F, Scalvini A
出版信息
Scand J Haematol. 1984 Jul;33(1):80-2. doi: 10.1111/j.1600-0609.1984.tb02214.x.
Abstract
The paper reports the occurrence of myocardial infarctions in a patient with severe deficiency of blood coagulation factor XII (Hageman factor). Factor XII plays a central role in the intrinsic activation of fibrinolysis and consequently the defective intrinsic fibrinolytic activity detected in the present case casts some doubt on its role in the increased vulnerability to thrombotic accident.
摘要
该论文报道了一名严重缺乏凝血因子XII（哈格曼因子）的患者发生心肌梗死的情况。凝血因子XII在纤维蛋白溶解的内源性激活中起核心作用，因此在本病例中检测到的内源性纤维蛋白溶解活性缺陷，对其在增加血栓形成意外易感性方面的作用提出了一些质疑。
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