Fernandes Hermina D, Newton Shauna, Rodrigues Jonathan M
Internal Medicine, University of North Dakota School of Medicine and Health Sciences, Bismarck, USA.
Cureus. 2018 Jun 15;10(6):e2817. doi: 10.7759/cureus.2817.
Factor XII (FXII), also known as Hageman factor, is a coagulation protein that is necessary for the functioning of the intrinsic coagulation cascade and fibrin formation. When deficient, it results in a significant prolongation of activated partial thromboplastin time (aPTT), mimicking a bleeding disorder. However, it does not result in clinical bleeding tendency. We report a case of an elderly male who was found to have prolonged aPTT, discovered during preoperative evaluation for operative repair of hip fracture. Although laboratory investigation was suggestive of bleeding tendency, he was diagnosed with factor XII deficiency and had no bleeding complications intra-operatively or in the post-operative period.
凝血因子 XII（FXII），也称为哈格曼因子，是一种凝血蛋白，对于内源性凝血级联反应和纤维蛋白形成的功能是必需的。当缺乏时，它会导致活化部分凝血活酶时间（aPTT）显著延长，类似于出血性疾病。然而，它不会导致临床出血倾向。我们报告一例老年男性病例，该患者在因髋部骨折手术修复进行术前评估时发现 aPTT 延长。尽管实验室检查提示有出血倾向，但他被诊断为凝血因子 XII 缺乏，术中及术后均无出血并发症。
