氧托溴铵治疗慢性支气管炎的剂量反应研究。
A dose response study of oxitropium bromide in chronic bronchitis.
作者信息
Peel E T, Anderson G
出版信息
Thorax. 1984 Jun;39(6):453-6. doi: 10.1136/thx.39.6.453.
Abstract
In a dose response study 12 patients with chronic bronchitis and airflow obstruction received inhaled placebo and incremental doses of oxitropium bromide. Significant improvements in peak expiratory flow rate, forced expiratory volume in one second, and forced vital capacity were recorded at all times up to 10 hours after all doses of oxitropium bromide. Oxitropium bromide is an effective bronchodilator in chronic bronchitis with an optimal dose of 400-600 micrograms.
摘要
在一项剂量反应研究中，12名患有慢性支气管炎和气流阻塞的患者吸入了安慰剂以及递增剂量的氧托溴铵。在所有剂量的氧托溴铵给药后长达10小时的所有时间点，均记录到呼气峰值流速、一秒用力呼气量和用力肺活量有显著改善。氧托溴铵是慢性支气管炎的一种有效支气管扩张剂，最佳剂量为400 - 600微克。
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本文引用的文献
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Peak expiratory flow in normal subjects.正常受试者的呼气峰值流速。
Br Med J. 1973 Aug 4;3(5874):282-4. doi: 10.1136/bmj.3.5874.282.
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