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Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjects.吸入白三烯C4、白三烯D4和组胺对正常人体受试者的比较效应。
Thorax. 1984 Jul;39(7):500-4. doi: 10.1136/thx.39.7.500.
2
Bronchial effects of leukotriene D4 inhalation in normal human lung.
Clin Sci (Lond). 1987 May;72(5):585-92. doi: 10.1042/cs0720585.
3
Leukotrienes C4, D4, and E4 enhance histamine responsiveness in asthmatic airways.白三烯C4、D4和E4可增强哮喘气道对组胺的反应性。
Am Rev Respir Dis. 1991 Nov;144(5):1053-7. doi: 10.1164/ajrccm/144.5.1053.
4
Asthmatic airways have a disproportionate hyperresponsiveness to LTE4, as compared with normal airways, but not to LTC4, LTD4, methacholine, and histamine.与正常气道相比，哮喘气道对白三烯E4具有不成比例的高反应性，但对白三烯C4、白三烯D4、乙酰甲胆碱和组胺则不然。
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A new method for measuring airway resistance in man using a body plethysmograph: values in normal subjects and in patients with respiratory disease.一种使用体容积描记器测量人体气道阻力的新方法：正常受试者和呼吸系统疾病患者的测量值。
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Structure of slow-reacting substance of anaphylaxis from guinea-pig lung.豚鼠肺过敏反应慢反应物质的结构
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Standardization of inhalation provocation tests: two techniques of aerosol generation and inhalation compared.吸入激发试验的标准化：两种气雾剂产生和吸入技术的比较
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Bronchoconstrictor effects of leukotriene C in humans.白三烯C对人体的支气管收缩作用。
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Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro.白三烯C-1和D在体内和体外的气道与血管活性比较
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Airway constriction in normal humans produced by inhalation of leukotriene D. Potency, time course, and effect of aspirin therapy.
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Effects of leukotriene D on the airways in asthma.白三烯D对哮喘气道的影响。
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In vitro and in vivo mechanisms of leukotriene-mediated bronchoconstriction in the guinea pig.豚鼠中白三烯介导支气管收缩的体外和体内机制
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9
Pharmacological activity of leukotrienes A4, B4, C4 and D4 on selected guinea-pig, rat, rabbit and human smooth muscles.白三烯A4、B4、C4和D4对选定的豚鼠、大鼠、兔子及人类平滑肌的药理活性。
Prostaglandins Med. 1981 Oct;7(4):327-40. doi: 10.1016/0161-4630(81)90137-3.
10
Identification of the C(6)-S-conjugate of leukotriene A with cysteine as a naturally occurring slow reacting substance of anaphylaxis (SRS-A). Importance of the 11-cis-geometry for biological activity.鉴定白三烯A与半胱氨酸的C(6)-S缀合物作为一种天然存在的过敏反应慢反应物质（SRS-A）。11-顺式构型对生物活性的重要性。
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吸入白三烯C4、白三烯D4和组胺对正常人体受试者的比较效应。

Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjects.

作者信息

Barnes N C, Piper P J, Costello J F

出版信息

Thorax. 1984 Jul;39(7):500-4. doi: 10.1136/thx.39.7.500.

DOI:10.1136/thx.39.7.500
PMID:6463929
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC459849/
Abstract

The comparative actions of inhaled leukotriene C4 (LTC4), leukotriene D4 (LTD4), and histamine were studied in six normal subjects. LTC4 and LTD4 were shown to be more potent bronchoconstrictors than histamine, with a more sustained action. LTC4 and LTD4 caused wheezing without cough or throat irritation and were shown to act on large and small airways.

摘要

在六名正常受试者中研究了吸入白三烯C4（LTC4）、白三烯D4（LTD4）和组胺的相对作用。结果显示，LTC4和LTD4作为支气管收缩剂比组胺更有效，且作用更持久。LTC4和LTD4可引发喘息但无咳嗽或咽喉刺激症状，表明其作用于大气道和小气道。