吸入白三烯C4、白三烯D4和组胺对正常人体受试者的比较效应。
Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjects.
作者信息
Barnes N C, Piper P J, Costello J F
出版信息
Thorax. 1984 Jul;39(7):500-4. doi: 10.1136/thx.39.7.500.
Abstract
The comparative actions of inhaled leukotriene C4 (LTC4), leukotriene D4 (LTD4), and histamine were studied in six normal subjects. LTC4 and LTD4 were shown to be more potent bronchoconstrictors than histamine, with a more sustained action. LTC4 and LTD4 caused wheezing without cough or throat irritation and were shown to act on large and small airways.
摘要
在六名正常受试者中研究了吸入白三烯C4（LTC4）、白三烯D4（LTD4）和组胺的相对作用。结果显示，LTC4和LTD4作为支气管收缩剂比组胺更有效，且作用更持久。LTC4和LTD4可引发喘息但无咳嗽或咽喉刺激症状，表明其作用于大气道和小气道。
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