Weiss J W, Drazen J M, Coles N, McFadden E R, Weller P F, Corey E J, Lewis R A, Austen K F
Science. 1982 Apr 9;216(4542):196-8. doi: 10.1126/science.7063880.
Maximum expiratory flow rate at 30 percent of vital capacity above residual volume served as an index of airway obstruction in comparing the effects of leukotriene C and histamine administered by aerosol to five normal persons. Leukotriene C was 600 to 9500 times more potent than histamine on a molar basis in producing an equivalent decrement in the residual volume. The leukotriene C response was slow in onset and prolonged, reminiscent of the effects of aerosol allergen challenge in asthmatic allergic subjects.
在比较向五名正常人雾化吸入白三烯C和组胺的效果时，将高于残气量的肺活量30%时的最大呼气流量作为气道阻塞指标。按摩尔计算，在产生相当于残气量减少的效果方面，白三烯C的效力比组胺高600至9500倍。白三烯C的反应起效缓慢且持续时间长，这与哮喘过敏受试者雾化过敏原激发的效果相似。
