Kluge F, Hoppe-Seyler P, Gerok W
Z Gastroenterol. 1984 Jun;22(6):277-84.
Immunogenetics explain the influence of genetic dispositions and regulation mechanisms on the defence mechanisms of organisms. In this paper the interrelationship between immunogenetic findings and Crohn's disease, ulcerative colitis and glutensensitive enteropathy are presented. The association with HLA-antigens and the complement factors Bf and C 4 are described. An increased association of HLA-antigens with Crohn's disease and ulcerative colitis have not been observed, with one exception, the association between HLA-Bw 35 (53%) and ulcerative colitis in a particular ethnic group in Israel. In contrast, there is a distinct association between the complement allotype Bf-F and Crohn's disease (68%) and ulcerative colitis (50%), compared with controls (29%). Glutensensitive enteropathy shows no increased occurrence of complement factors however there is an association with HLA-B8 (83%) DR 3 (94%) and DR 7 (61%). The phenotype description of the genes of the main histocompatibility complexes allows, amongst others, a conclusion concerning the pathogenesis and diagnosis of certain diseases. A new approach to these diseases has been introduced.
免疫遗传学解释了遗传倾向和调节机制对生物体防御机制的影响。本文介绍了免疫遗传学研究结果与克罗恩病、溃疡性结肠炎和麸质敏感性肠病之间的相互关系。文中描述了与HLA抗原以及补体因子Bf和C4的关联。除了以色列一个特定种族群体中HLA - Bw35（53%）与溃疡性结肠炎之间的关联外，未观察到HLA抗原与克罗恩病和溃疡性结肠炎之间的关联增加。相比之下，与对照组（29%）相比，补体同种异型Bf - F与克罗恩病（68%）和溃疡性结肠炎（50%）之间存在明显关联。麸质敏感性肠病未显示补体因子出现增加，但与HLA - B8（83%）、DR3（94%）和DR7（61%）存在关联。主要组织相容性复合体基因的表型描述尤其有助于得出有关某些疾病发病机制和诊断的结论。针对这些疾病已引入了一种新方法。
