Rudenko L G, Zykov M P
Zh Mikrobiol Epidemiol Immunobiol. 1984 Jun(6):79-84.
The reactogenicity and antigenic potency of existing inactivated influenza vaccines were tested on 750 practically healthy adults. In all the preparations under test the levels of reactogenicity were found to correspond to the Technical Specifications TY--KBC, but the subunit type vaccine, "Gripovac", proved to possess the lowest reactogenicity and was, therefore, recommended for further trials in young children. Taking into account the characteristics of antigenic potency, the work gives grounds for the necessity of increasing the content of hemagglutinin in the vaccine prepared by the centrifugal method and for the practical use of the same volumetric dose (0.2 ml) for both virion vaccines (prepared by the centrifugal and chromatographic methods).
在750名基本健康的成年人身上测试了现有灭活流感疫苗的反应原性和抗原效力。在所有受试制剂中，发现反应原性水平符合技术规范TY-KBC，但亚单位型疫苗“Gripovac”的反应原性最低，因此建议在幼儿中进行进一步试验。考虑到抗原效力的特点，这项研究为增加离心法制备的疫苗中血凝素含量以及两种病毒体疫苗（离心法和色谱法制备）都实际使用相同体积剂量（0.2毫升）提供了依据。
