原发性胆汁性肝硬化中C1q结合增加与关节炎
Increased C1q binding and arthritis in primary biliary cirrhosis.
作者信息
Crowe J P, Molloy M G, Wells I, Thompson B R, Holborow E J, Hamilton E, Williams R
出版信息
Gut. 1980 May;21(5):418-22. doi: 10.1136/gut.21.5.418.
Using the C1q binding assay, circulating immune complexes were detected in 31 of 50 (62%) patients with primary biliary cirrhosis and 17 of these had arthritis. This took the form of a seropositive inflammatory polyarthritis in 12 of 18 patients with C1q binding greater than or equal to 20%, whereas a milder seronegative arthritis associated with scleroderma and Raynaud's phenomenon was found in five of 13 patients with C1q binding < 20%. Only two of the 19 patients with normal binding had arthritis and this was of a mild and transient nature. There was a positive correlation between C1q binding and the serum concentrations of IgG and IgM. Results also supported the hypothesis that circulating immune complexes may be involved in the development of arthritis in patients with primary biliary cirrhosis.
采用C1q结合试验，在50例原发性胆汁性肝硬化患者中的31例（62%）检测到循环免疫复合物，其中17例有关节炎。18例C1q结合≥20%的患者中有12例表现为血清反应阳性的炎性多关节炎，而13例C1q结合＜20%的患者中有5例出现与硬皮病和雷诺现象相关的较轻的血清反应阴性关节炎。19例结合正常的患者中只有2例有关节炎，且病情轻微、呈一过性。C1q结合与IgG和IgM的血清浓度之间呈正相关。结果也支持循环免疫复合物可能参与原发性胆汁性肝硬化患者关节炎发生的假说。
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