Hosenpud J D, Montanaro A, Hart M V, Haines J E, Specht H D, Bennett R M, Kloster F E
Am J Med. 1984 Aug;77(2):286-92. doi: 10.1016/0002-9343(84)90704-6.
Accelerated coronary artery disease and myocardial infarction in young patients with systemic lupus erythematosus is well documented; however, the prevalence of coronary involvement is unknown. Accordingly, 26 patients with systemic lupus were selected irrespective of previous cardiac history to undergo exercise thallium-201 cardiac scintigraphy. Segmental perfusion abnormalities were present in 10 of the 26 studies (38.5 percent). Five patients had reversible defects suggesting ischemia, four patients had persistent defects consistent with scar, and one patient had both reversible and persistent defects in two areas. There was no correlation between positive thallium results and duration of disease, amount of corticosteroid treatment, major organ system involvement or age. Only a history of pericarditis appeared to be associated with positive thallium-201 results (p less than 0.05). It is concluded that segmental myocardial perfusion abnormalities are common in patients with systemic lupus erythematosus. Whether this reflects large-vessel coronary disease or small-vessel abnormalities remains to be determined.
系统性红斑狼疮年轻患者中加速性冠状动脉疾病和心肌梗死已有充分文献记载；然而，冠状动脉受累的患病率尚不清楚。因此，选取了26例系统性红斑狼疮患者，不论其既往心脏病史，均接受运动铊-201心肌闪烁显像检查。26项研究中有10项（38.5%）出现节段性灌注异常。5例患者有提示缺血的可逆性缺损，4例患者有与瘢痕一致的持续性缺损，1例患者在两个区域同时有可逆性和持续性缺损。铊检查结果阳性与疾病持续时间、皮质类固醇治疗量、主要器官系统受累情况或年龄之间无相关性。仅心包炎病史似乎与铊-201检查结果阳性相关（P<0.05）。结论是节段性心肌灌注异常在系统性红斑狼疮患者中很常见。这是反映大血管冠状动脉疾病还是小血管异常仍有待确定。
