Stoica G, Koestner A
Am J Pathol. 1984 Aug;116(2):319-26.
In this study, 30-day-old male Sprague-Dawley rats, were inoculated intraperitoneally with a single dose of 45, 90, and 180 mg/kg of N-ethyl-N-Nitrosourea (ENU). A wide spectrum of neoplasms occurred. The most common tumors were those of the mammary gland and of the nervous system. Although the incidence of mammary tumors was highest in the two high-dose groups (90 and 180 mg/kg ENU), the incidence of neurogenic tumors was highest in the 45 mg/kg dose group. Mammary tumor development led to early death and precluded development of tumors of the nervous system, which require a longer latency period. A variety of neoplasms of other organs have been associated particularly with high doses of ENU, including ameloblastic tumors, carcinomas of the thyroid, prostate, kidney, pancreas, intestine, and lung, hemilymphatic tumors, and sarcomas. It is concluded that large doses of ENU are capable of expanding the tumor spectrum in young male rats beyond the target organs generally affected with lower doses, as described in earlier reports.
在本研究中，对30日龄的雄性斯普拉格-道利大鼠腹腔注射单剂量45、90和180 mg/kg的N-乙基-N-亚硝基脲（ENU）。出现了多种肿瘤。最常见的肿瘤是乳腺肿瘤和神经系统肿瘤。虽然乳腺肿瘤的发生率在两个高剂量组（90和180 mg/kg ENU）中最高，但神经源性肿瘤的发生率在45 mg/kg剂量组中最高。乳腺肿瘤的发展导致早期死亡，并排除了神经系统肿瘤的发生，因为神经系统肿瘤需要更长的潜伏期。其他器官的多种肿瘤尤其与高剂量的ENU有关，包括成釉细胞瘤、甲状腺癌、前列腺癌、肾癌、胰腺癌、肠癌和肺癌、半淋巴管肿瘤和肉瘤。得出的结论是，如早期报告所述，大剂量的ENU能够使年轻雄性大鼠的肿瘤谱超出通常受较低剂量影响的靶器官范围。
