• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

人类补体成分3基因内两个多态性位点之间的近似连锁平衡。

Approximate linkage equilibrium between two polymorphic sites within the gene for human complement component 3.

作者信息

Donald J A, Ball S P

出版信息

Ann Hum Genet. 1984 Jul;48(3):269-73. doi: 10.1111/j.1469-1809.1984.tb01024.x.

DOI:10.1111/j.1469-1809.1984.tb01024.x
PMID:6465843
Abstract

Haplotypes have been determined for alleles at two separate polymorphic sites within the human structural gene for complement component 3, identified as a protein polymorphism and as a restriction fragment length polymorphism by hybridization using a cloned gene probe. No evidence was found for appreciable disequilibrium between alleles at these sites, despite their very close linkage.

摘要

已确定人类补体成分3结构基因内两个独立多态性位点上等位基因的单倍型,通过使用克隆基因探针杂交将其鉴定为蛋白质多态性和限制性片段长度多态性。尽管这些位点上的等位基因紧密连锁,但未发现它们之间存在明显不平衡的证据。

相似文献

1
Approximate linkage equilibrium between two polymorphic sites within the gene for human complement component 3.人类补体成分3基因内两个多态性位点之间的近似连锁平衡。
Ann Hum Genet. 1984 Jul;48(3):269-73. doi: 10.1111/j.1469-1809.1984.tb01024.x.
2
Restriction fragment length polymorphism of the human C3 complement gene.
Exp Clin Immunogenet. 1986;3(1):34-7.
3
Localization of cloned unique DNA to three different regions of chromosome 19: screen for linkage probes for myotonic dystrophy.克隆的单一DNA在19号染色体三个不同区域的定位:强直性肌营养不良连锁探针的筛选
J Neurogenet. 1985 Dec;2(6):403-12. doi: 10.3109/01677068509101426.
4
Linkage relationships of the insulin receptor gene with the complement component 3, LDL receptor, apolipoprotein C2 and myotonic dystrophy loci on chromosome 19.胰岛素受体基因与19号染色体上补体成分3、低密度脂蛋白受体、载脂蛋白C2及强直性肌营养不良基因座的连锁关系。
Hum Genet. 1986 Nov;74(3):267-9. doi: 10.1007/BF00282546.
5
Genetics and linkage relationships of the C3 polymorphism: discovery of C3-Se linkage and assignment of LES-C3-DM-Se-PEPD-Lu synteny to chromosome 19.C3多态性的遗传学及连锁关系:C3与硒(Se)的连锁发现以及LES-C3-DM-Se-PEPD-Lu同线性群在19号染色体上的定位
Clin Genet. 1983 Sep;24(3):159-70. doi: 10.1111/j.1399-0004.1983.tb02233.x.
6
Three-point linkage analysis employing C3 and 19cen markers assigns the myotonic dystrophy gene to 19q.
Hum Genet. 1987 Mar;75(3):291-3. doi: 10.1007/BF00281077.
7
The use of polymorphic DNA and protein markers for the third complement component for determining linkage of familial hypercholesterolaemia.利用多态性DNA和蛋白质标记物检测第三补体成分,以确定家族性高胆固醇血症的连锁关系。
Atherosclerosis. 1984 Sep;52(3):267-78. doi: 10.1016/0021-9150(84)90056-x.
8
Linkage analysis of myotonic dystrophy and sequences on chromosome 19 using a cloned complement 3 gene probe.使用克隆的补体3基因探针进行强直性肌营养不良与19号染色体序列的连锁分析。
J Med Genet. 1983 Aug;20(4):259-63. doi: 10.1136/jmg.20.4.259.
9
Linkage relationships of the protein kinase C gamma gene which exclude it as a candidate for myotonic dystrophy.蛋白激酶Cγ基因的连锁关系排除了其作为强直性肌营养不良候选基因的可能性。
Cytogenet Cell Genet. 1988;48(1):13-5. doi: 10.1159/000132577.
10
Linkage relationships of the gene for apolipoprotein CII with loci on chromosome 19.
Hum Genet. 1985;69(1):39-43. doi: 10.1007/BF00295527.

引用本文的文献

1
The isolation of a genomic clone containing the apolipoprotein CII gene and the detection of linkage disequilibrium between two common DNA polymorphisms around the gene.包含载脂蛋白CII基因的基因组克隆的分离以及该基因周围两个常见DNA多态性之间连锁不平衡的检测。
Hum Genet. 1984;68(4):286-9. doi: 10.1007/BF00292585.
2
Genetic analysis of eight linked polymorphisms within the human immunoglobulin heavy-chain region.人类免疫球蛋白重链区域内八个连锁多态性的遗传分析。
Am J Hum Genet. 1985 Nov;37(6):1146-63.
3
Linkage relationships of the gene for apolipoprotein CII with loci on chromosome 19.
Hum Genet. 1985;69(1):39-43. doi: 10.1007/BF00295527.
4
A new restriction fragment length polymorphism in the haptoglobin gene region.触珠蛋白基因区域的一种新的限制性片段长度多态性
Hum Genet. 1985;70(1):66-70. doi: 10.1007/BF00389461.
5
Molecular basis of polymorphisms of human complement component C3.人类补体成分C3多态性的分子基础
J Exp Med. 1990 Oct 1;172(4):1011-7. doi: 10.1084/jem.172.4.1011.
6
Albumin--vitamin D-binding protein haplotypes in Asian-Pacific populations.亚太人群中的白蛋白-维生素D结合蛋白单倍型
Hum Genet. 1990 Jun;85(1):89-97. doi: 10.1007/BF00276330.