Three-point linkage analysis employing C3 and 19cen markers assigns the myotonic dystrophy gene to 19q.
作者信息
Friedrich U, Brunner H, Smeets D, Lambermon E, Ropers H H
出版信息
Hum Genet. 1987 Mar;75(3):291-3. doi: 10.1007/BF00281077.
PMID:2881880
Abstract
In seven large families with myotonic dystrophy (DM) comprising 102 individuals, linkage studies were performed employing restriction fragment length polymorphisms in the complement component 3 gene and the 19cen C banding heteromorphism as genetic markers. Three-point linkage analysis excludes DM from the 19cen-C3 segment and strongly supports its assignment to the proximal long arm of chromosome 19.
摘要
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