C反应蛋白检测在结核性、细菌性和病毒性脑膜炎中的价值。
Value of C reactive protein measurement in tuberculous, bacterial, and viral meningitis.
作者信息
de Beer F C, Kirsten G F, Gie R P, Beyers N, Strachan A F
出版信息
Arch Dis Child. 1984 Jul;59(7):653-6. doi: 10.1136/adc.59.7.653.
The value of C reactive protein measurement in the differential diagnosis of meningitis was assessed in a population where tuberculous meningitis is prevalent. C reactive protein was measured serially with a sensitive radioimmunoassay in sera from 31 children with bacterial meningitis, 15 with tuberculous meningitis (6 with miliary tuberculosis), and 28 with viral meningitis. Concentrations of C reactive protein in patients with tuberculous meningitis lay between those of patients with bacterial and viral meningitis--a finding which detracts from the virtually absolute discrimination C reactive protein measurement allows between bacterial and viral meningitis. In all but two of the patients with tuberculous meningitis, C reactive protein concentrations fell rapidly after treatment began and became normal after 10 days. This fall did not, however, exclude the development of hydrocephalus as a complication. Measurement of C reactive protein remains a useful additional parameter in the diagnosis and management of the various types of meningitis.
在结核性脑膜炎流行的人群中，评估了C反应蛋白检测在脑膜炎鉴别诊断中的价值。采用灵敏的放射免疫分析法，对31例细菌性脑膜炎患儿、15例结核性脑膜炎患儿（6例合并粟粒性肺结核）和28例病毒性脑膜炎患儿的血清进行了C反应蛋白的连续检测。结核性脑膜炎患者的C反应蛋白浓度介于细菌性脑膜炎和病毒性脑膜炎患者之间，这一发现削弱了C反应蛋白检测在鉴别细菌性和病毒性脑膜炎方面几乎绝对的区分能力。除2例结核性脑膜炎患者外，所有患者在开始治疗后C反应蛋白浓度迅速下降，并在10天后恢复正常。然而，这种下降并不排除脑积水作为并发症的发生。C反应蛋白检测仍然是各类脑膜炎诊断和管理中一个有用的附加参数。
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