An inverse relationship between heparin content and antibody response in genetically selected mice. Sex effect and evidence of a polygenic control for skin heparin concentration.

The heparin content of genetically selected mice with high and low antibody response to bacterial antigens is reported. An inverse relationship between antibody titres and concentration of heparin was observed for both male and female mice. The lower-antibody-responder line contains twice as much heparin as the higher-responder ones. Furthermore, the female mice also contained twice as much heparin as the male mice. Genetic analysis of the parental and interline hybrids has shown a partial dominance for the character 'heparin content' in favour of the high-heparin phenotype and this character appears to be subjected to polygenic control. The possible biological role of heparin and/or mast cells in the surveillance of the organism against some pathogens is discussed in the light of these and other findings.