Weisz D J, Clark G A, Thompson R F
Behav Brain Res. 1984 May;12(2):145-54. doi: 10.1016/0166-4328(84)90037-8.
We examined the responsivity of dentate gyrus granule cells to perforant path stimulation during classical conditioning of the rabbit nictitating membrane response. Dentate field potentials elicited by perforant path stimulation were recorded during training to test for changes in granule cell responsivity. Results showed above-baseline increases in dentate population spike amplitudes over the course of training in paired but not unpaired animals. In addition, population spike amplitudes were smaller when elicited during tone presentations in both paired and unpaired animals than between trials when no conditioning stimuli were present. While alternative interpretations remain, these results provide preliminary evidence that processes similar to long-term potentiation may occur in the hippocampus during behavioral conditioning.
我们在兔瞬膜反应的经典条件反射过程中，研究了齿状回颗粒细胞对穿通通路刺激的反应性。在训练期间记录穿通通路刺激诱发的齿状场电位，以测试颗粒细胞反应性的变化。结果显示，在配对而非未配对动物的训练过程中，齿状群体锋电位幅度高于基线水平。此外，在配对和未配对动物的音调呈现期间诱发的群体锋电位幅度，均小于无条件刺激时试验之间诱发的幅度。尽管仍有其他解释，但这些结果提供了初步证据，表明在行为条件反射过程中，海马体中可能发生类似于长时程增强的过程。
