Bartness T J, Wade G N
Behav Neurosci. 1984 Aug;98(4):674-85. doi: 10.1037//0735-7044.98.4.674.
Ovariectomy-induced increases and estradiol-induced decreased in body weight cannot be fully accounted for by changes in energy intake and appear to reflect alterations in thermogenesis. Because changes in energy expenditure have been linked to altered sympathetic nervous system (SNS) activity in brown adipose tissue (BAT), the role of estradiol in thermogenesis and body weight, as mediated by the SNS innervation of interscapular BAT (IBAT), was examined. The IBAT of ovariectomized rats was bilaterally or unilaterally surgically denervated. The chow-fed, bilaterally denervated group gained more weight than the unilaterally denervated or sham-operated group, an effect that was exaggerated by sucrose feeding. Food intake did not differ among the groups within each dietary condition. Estradiol benzoate (EB) injections decreased body weight in all groups. Bilateral, and to a lesser extent, unilateral IBAT denervation blocked the EB-induced increase in thermogenesis. Treatment with EB increased IBAT wet weight regardless of surgical treatment. Because IBAT denervation markedly decreased lipoprotein lipase activity and fatty acid synthesis/uptake, the estradiol-induced increase in denervated IBAT wet weight is most likely due to decreased lipolysis produced by the surgical sympathectomy. These results are discussed in terms of the role of the SNS and IBAT in the mediation of estradiol-induced changes in body weight and energy metabolism.
卵巢切除引起的体重增加以及雌二醇引起的体重减轻，不能完全用能量摄入的变化来解释，似乎反映了产热的改变。由于能量消耗的变化与棕色脂肪组织（BAT）中交感神经系统（SNS）活动的改变有关，因此研究了雌二醇在由肩胛间BAT（IBAT）的SNS神经支配介导的产热和体重方面的作用。对去卵巢大鼠的IBAT进行双侧或单侧手术去神经支配。喂食普通饲料的双侧去神经支配组比单侧去神经支配组或假手术组体重增加更多，蔗糖喂养会加剧这种影响。在每种饮食条件下，各组之间的食物摄入量没有差异。注射苯甲酸雌二醇（EB）可使所有组的体重减轻。双侧以及在较小程度上单侧IBAT去神经支配可阻断EB诱导的产热增加。无论手术处理如何，EB处理均可增加IBAT湿重。由于IBAT去神经支配显著降低了脂蛋白脂肪酶活性和脂肪酸合成/摄取，因此雌二醇诱导的去神经支配IBAT湿重增加很可能是由于手术交感神经切除术导致的脂解作用降低。根据SNS和IBAT在介导雌二醇诱导的体重和能量代谢变化中的作用对这些结果进行了讨论。
