Therapy with high dose recombinant alpha 2 interferon (IFN-alpha 2) produces a depression in natural killer cell cytotoxicity.
作者信息
Tank B, Marquet R L, Weimar W, Westbroek D L
出版信息
Br J Cancer. 1984 Aug;50(2):227-30. doi: 10.1038/bjc.1984.167.
Abstract
摘要
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Therapy with high dose recombinant alpha 2 interferon (IFN-alpha 2) produces a depression in natural killer cell cytotoxicity.
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Clinical and immunological evaluation of 20 patients with advanced colorectal cancer treated with high dose recombinant leukocyte interferon-alpha A (rIFN alpha A).对20例接受高剂量重组白细胞干扰素αA（rIFNαA）治疗的晚期结直肠癌患者的临床和免疫学评估。
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本文引用的文献
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Depression of natural killer cytotoxicity after in vivo administration of recombinant leukocyte interferon.体内给予重组白细胞干扰素后自然杀伤细胞细胞毒性的降低
J Immunol. 1983 Jul;131(1):503-7.
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Modulation of natural killer cell-mediated cytotoxicity by partially purified and cloned interferon-alpha.
Cancer Res. 1982 Jun;42(6):2480-8.
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Purification and characterization of recombinant human leukocyte interferon (IFLrA) with monoclonal antibodies.利用单克隆抗体对重组人白细胞干扰素（IFLrA）进行纯化与特性鉴定
J Biol Chem. 1981 Sep 25;256(18):9750-4.
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Interferon and spontaneous cytotoxicity in man. V. Enhancement of spontaneous cytotoxicity in patients receiving human leukocyte interferon.
Int J Cancer. 1980 Oct 15;26(4):419-28. doi: 10.1002/ijc.2910260406.
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Cytotoxic reactivity of human lymphocytes cultured in vitro.体外培养的人淋巴细胞的细胞毒性反应性。
J Immunol. 1977 Oct;119(4):1351-7.
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Interferon and spontaneous cytotoxicity in man. I. Enhancement of the spontaneous cytotoxicity of peripheral lymphocytes by human leukocyte interferon.
Int J Cancer. 1978 Oct 15;22(4):405-12. doi: 10.1002/ijc.2910220407.
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Human natural killer cell activity is augmented by interferon via recruitment of 'pre-NK' cells.
Scand J Immunol. 1979;10(3):257-66. doi: 10.1111/j.1365-3083.1979.tb01348.x.
9
Induction and kinetics of natural killer cells in humans following interferon therapy.
Nature. 1979 Nov 22;282(5737):417-9. doi: 10.1038/282417a0.
10
Electrophoretically pure mouse interferon exerts multiple biologic effects.经电泳纯的小鼠干扰素具有多种生物学效应。
Proc Natl Acad Sci U S A. 1979 Oct;76(10):5308-12. doi: 10.1073/pnas.76.10.5308.
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