经电泳纯的小鼠干扰素具有多种生物学效应。
Electrophoretically pure mouse interferon exerts multiple biologic effects.
作者信息
Gresser I, De Maeyer-Guignard J, Tovey M G, De Maeyer E
出版信息
Proc Natl Acad Sci U S A. 1979 Oct;76(10):5308-12. doi: 10.1073/pnas.76.10.5308.
Abstract
Electrophoretically pure mouse interferon was examined for a number of biologic effects previously ascribed to crude or partially purified interferon preparations. These effects include: inhibition of the growth of a transplantable tumor in mice; inhibition of cell multiplication of mouse tumor cells in vitro; enhancement of the expression of histocompatibility antigens on mouse tumor cells in vitro; inhibition of antibody formation in vitro; inhibition of sensitization to sheep erythrocytes and the expression of delayed type hypersensitivity in mice; enhancement of natural killer cell activity in vivo and in vitro; enhancement of cell sensitivity to the toxicity of poly(I)-poly(C); and enhanced production ("priming") of interferon production in vitro. Our results establish that the molecules responsible for the antiviral action of interferon are also responsible for these varied biologic effects.
摘要
对电泳纯的小鼠干扰素进行了检测，以观察先前归因于粗制或部分纯化干扰素制剂的多种生物学效应。这些效应包括：抑制小鼠可移植肿瘤的生长；抑制小鼠肿瘤细胞在体外的增殖；增强小鼠肿瘤细胞在体外组织相容性抗原的表达；抑制体外抗体形成；抑制对绵羊红细胞的致敏作用以及小鼠迟发型超敏反应的表达；增强体内和体外自然杀伤细胞的活性；增强细胞对聚肌苷酸-聚胞苷酸（poly(I)-poly(C)）毒性的敏感性；以及增强体外干扰素产生（“启动”）。我们的结果表明，负责干扰素抗病毒作用的分子也负责这些多样的生物学效应。
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Increased survival in mice inoculated with tumor cells and treated with interferon preparations.接种肿瘤细胞并接受干扰素制剂治疗的小鼠存活率提高。
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