乙酰唑胺治疗丙酮酸代谢异常综合征
Acetazolamide in the treatment of pyruvate dysmetabolism syndromes.
作者信息
Evans O B, Kilroy A W, Fenichel G M
出版信息
Arch Neurol. 1978 May;35(5):302-5. doi: 10.1001/archneur.1978.00500290048008.
Abstract
Two children with periodic weakness beginning in infancy were demonstrated to have abnormalities in pyruvate metabolism by the production of lactic acidosis following a glucose load. Daily oral doses of acetazolamide reduced the frequency of attacks and reversed the abnormal response to glucose loading. The mechanism of action of acetazolamide in these patients is not clear.
摘要
两名自婴儿期起就出现周期性肌无力的儿童，经证实因葡萄糖负荷后出现乳酸性酸中毒而存在丙酮酸代谢异常。每日口服乙酰唑胺可减少发作频率，并逆转对葡萄糖负荷的异常反应。乙酰唑胺在这些患者中的作用机制尚不清楚。
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