Griggs R C, Moxley R T, Lafrance R A, McQuillen J
Neurology. 1978 Dec;28(12):1259-64. doi: 10.1212/wnl.28.12.1259.
From early childhood, eight patients in a kindred had paroxysmal bouts of ataxia, dysarthria, and nystagmus. The disorder was inherited as an autosomal dominant. Attacks occurred weekly and lasted 1 to 6 hours; there were slight cerebellar signs between attacks. Although the etiology was not determined, a serendipitous trial of acetazolamide completely abolished attacks, and all patients have remained free of attacks for as long as 5 years.
