Ul'ianov A M, Tarasov Iu A
Nauchnye Doki Vyss Shkoly Biol Nauki. 1984(8):48-51.
It has been shown that the development of alloxan diabetes in rats and the appearance of diabetogenic factor in blood is caused by the direct alloxan action on pancreas and spleen--the organs supplying by blood through the spleen artery. The stopping of blood circulation in that artery preserves rat's organism from the development of general toxic effect of alloxan. The inactivation of alloxan as a diabetogenic agent has been shown after its 5-minute at 37 degrees C incubation with blood. It has been established that the half activity of intravenous injected alloxan disappears in rat's organism during 50 s. and does not depend on alloxan sensitivity of animals.
业已表明，大鼠中四氧嘧啶糖尿病的发展以及血液中致糖尿病因子的出现是由四氧嘧啶对胰腺和脾脏的直接作用所引起的，胰腺和脾脏是通过脾动脉供血的器官。阻断该动脉的血液循环可使大鼠机体免受四氧嘧啶全身毒性作用的影响。四氧嘧啶与血液在37℃孵育5分钟后，其作为致糖尿病剂的活性被灭活。已经确定，静脉注射的四氧嘧啶在大鼠机体内50秒内其活性减半，且这与动物对四氧嘧啶的敏感性无关。
